7925 NE 221ST STREET
MELROSE, FL 32666
$650,000
Beds: 2
Baths: 2
Sq. Ft.: 1,512
Type: House
Rare Opportunity on Big Lake Santa Fe! Lovingly cared for by the same family for over 60 years, this charming lakefront retreat offers the perfect blend of history, comfort, and modern updates. Nestled on the prestigious Big Lake Santa Fe, this 2-bedroom, 2-bath home spans 1,512 sq ft all on one level, making it ideal for year-round living or a relaxing weekend getaway. Step inside to discover a thoughtfully renovated interior with upgraded electric, plumbing, kitchen, bathrooms, and a durable metal roof for peace of mind. The spacious primary suite features a large walk-in closet and private ensuite bath. Outside, you'll find beautifully mature landscaping, a carport, a storage shed, and a large workshop with its own covered parking area--perfect for hobbies or additional storage. But the crown jewel is the waterfront: enjoy your mornings and evenings on the private dock, relax under the covered gazebo, or take full advantage of the boathouse for all your lake toys. With deep water access, this lake is a dream for fishing, swimming, and boating right from your own front yard. Don't miss your chance to own a piece of paradise on one of North Florida's most sought-after lakes!
Property Features
County: Alachua
MLS Area: Melrose
Latitude: 29.72755
Longitude: -82.088452
Subdivision: SANTA FE SHORES
Location: Paved
Directions: SR 26 TOWARD GAINESVILLE FROM MELROSE TURN RIGHT ON NE 221ST ST CONTINUE STRAIGHT WHERE PAVEMENT ENDS. PROPERTY ON RIGHT
Development: Santa Fe Shores
Interior: Ceiling Fans(s), Open Floorplan, Split Bedroom, Walk-In Closet(s)
Full Baths: 2
Has Fireplace: Yes
Fireplace Description: Gas
Heat/Cool: Central
Cooling: Central Air
Floors: Carpet, Laminate, Wood
Appliances: Dishwasher, Dryer, Electric Water Heater, Range, Refrigerator, Washer
Has Private Pool: No
Style: Cottage
Water View: Lake
Stories: One
Stories: Single story
Direction Faces: Northeast
Is New Construction: No
Construction: Frame
Exterior: Other
Foundation: Slab
Roof: Metal
Water Extras: Boathouse
Utilities: Electricity Connected
Parking Description: Covered
Has Garage: No
Lot Description: 1/4 to less than 1/2
Lot Number: 3
Lot Size in Acres: 0.31
Lot Size in Sq. Ft.: 13,504
Zoning: A
Flood Zone Code: X
Water Body: BIG LAKE SANTA FE
Water Frontage: 66
Waterfront Description: Lake Front
Has Waterfront: Yes
Water Access: Lake
Is One Story: Yes
Property Type: SFR
Property SubType: Single Family Residence
Year Built: 1941
Status: Active
Housing For Older Persons (55+): No
Tax Amount: $2,873
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Listing Courtesy of CB ISAAC REALTY 352-475-2199

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Stellar (MFR) data last updated at July 4, 2025, 11:20 PM ET
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